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Table 1 Genes from 22 k Arabidopsis ATH1 array that have the highest correlation across 965 chips with the hub genes.

From: Articulation of three core metabolic processes in Arabidopsis: Fatty acid biosynthesis, leucine catabolism and starch metabolism

Hub Gene: MCCB, At4g34030, methylcrotonyl-CoA carboxylase, subunit B, leucine catabolism
Corr. GeneID Description
0.9 At1g03090 MCCA, methylcrotonyl-CoA carboxylase, subunit A
0.84 At3g06850 BCE2, E2 subunit of branched chain alpha-ketoacid dehydrogenase
0.84 At3g13450 DIN4, E1 beta subunit of branched-chain alpha-keto acid dehydrogenase
0.82 At2g43400 electron transfer flavoprotein: ubiquinone oxidoreductase family protein
0.8 At3g45300 IVD, isovaleryl-CoA dehydrogenase
0.8 At4g35770 Senescence-associated protein (SEN1)
0.79 At5g21170 AMP-activated protein kinase
0.78 At1g08630 threonine aldolase
0.78 At1g15040 glutamine amidotransferase-related
0.77 At1g10070 BCAT2, branched-chain amino acid transaminase
0.74 At4g28040 nodulin MtN21 family protein
0.73 At3g47340 glutamine-dependent asparagine synthetase 1 (ASN1)
0.73 At1g21400 E1 alpha subunit of branched-chain alpha-keto acid dehydrogenase, BCDH_E1a2
0.72 At1g18270 ketose-bisphosphate aldolase class-II family protein
0.71 At5g49450* bZIP family transcription factor
0.71 At1g55510 BCDH BETA1, E1 beta subunit of branched-chain alpha-keto acid dehydrogenase
0.7 At3g49790 expressed protein
Hub Gene: DE2, At2g40840, disproportionating enzyme, starch metabolism
Corr. GeneID Description
0.89 At3g46970 PHS2, starch phosphorylase
0.85 At1g10760 GWD1, glucan water dikinase
0.85 At3g52180* SEX4, protein tyrosine phosphatase/kinase
0.8 At1g03310 ISA2, isoamylase DB
0.79 At4g09020 ISA3, isoamylase DB
0.76 At1g06460 31.2 kDa small heat shock family protein/hsp20 family protein
0.74 At5g26570 GWD2, glucan water dikinase
0.74 At3g29320 PHS1, starch phosphorylase
0.73 At5g59130 subtilase family protein
0.73 At2g39920 acid phosphatase class B family protein
0.72 At1g69830 AAM3, alpha-amylase
0.72 At1g67660 expressed protein
0.71 At3g18500 similar to endonuclease/exonuclease/phosphatase family protein
0.7 At2g31040 ATP synthase protein I-related
0.7 At4g33490 nucellin-like protein
Hub Gene: MOD1, At2g05990, enoyl reductase, fatty acid biosynthesis
Corr. GeneID Description
0.86 At1g34430 PDHC_E2, acetyltransferase subunit of pyruvate dehydrogenase
0.86 At5g10160 HD, 3-hydroxyacyl-[ACP] dehydratase
0.84 At5g35360 CAC2, biotin carboxylase subunit of heteromeric acetyl-CoA carboxylase
0.83 At5g46290 KASI, 3-ketoacyl-[ACP] synthase I
0.8 At2g30200 MAT, malonyl-CoA:ACP transacylase
0.8 At3g16950 LPD1, lipoamide dehydrogenase subunit of pyruvate dehydrogenase
0.79 At1g62640 KAS III, 3-ketoacyl-[ACP] synthase III
0.78 At1g53520$ chalcone-flavanone isomerase-related
0.77 At3g25860 LTA2, acetyltransferase subunit of pyruvate dehydrogenase
0.77 At5g52920 pyruvate kinase
0.76 At5g16390 BCCP1, biotin carboxyl carrier subunit of heteromeric acetyl-CoA carboxylase
0.75 At5g08415 LIP1-like, lipoate synthase
0.73 At2g22230 HD-like, 3-hydroxyacyl-[ACP] dehydratase
0.72 At1g30120 PDHC_E1beta2, E1 beta subunit of plastidic pyruvate dehydrogenase
0.72 At5g15530 BCCP2, biotin carboxyl carrier subunit of heteromeric acetyl-CoA carboxylase
0.71 At1g01090 PDHC_E1alpha, E1 alpha subunit of plastidic pyruvate dehydrogenase
0.71 At5g50390* pentatricopeptide (PPR) repeat-containing protein
0.7 At4g12700 expressed protein
  1. Genes used as the hub (at the top of the table) are methylcrotonyl-CoA carboxylase (MCCB), active in leucine degradation in mitochondria; disproportionating enzyme (DE2), from starch metabolism; and enoyl reductase (MOD1), an enzyme from plastidic fatty acid biosynthesis pathway. Genes that code for proteins predicted to be in the same pathway as the hub gene are in bold font. Potential regulatory genes are marked with an asterisk. Pearson coefficients (> 0.7) were calculated by MetaOmGraph. P-values for enrichment of genes from same pathway as hub are 4.35e-36, 2.02e-15, and 3.1e-23, respectively.
  2. $ This gene product, although annotated as chalcone isomerase-like, appears to have a direct role in binding and possibly transporting fatty acids (Joe Noel and Florence Pojer, personal communication).