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Figure 7 | BMC Plant Biology

Figure 7

From: The AtRAD21.1 and AtRAD21.3 Arabidopsis cohesins play a synergistic role in somatic DNA double strand break damage repair

Figure 7

Proposed model: AtRAD21.1 and AtRAD21.3 before and after induction of DNA dsb damage. (A) Before the induction of DNA dsb, sister chromatid cohesion is promoted by AtRAD21.3 (green rings), and possibly also by some AtRAD21.1 (red rings) associated with DNA dsb created by endogenous factors. (B) After the induction of DNA dsb breaks (flash), AtRAD21.1 expression is enhanced. This is expected to increase the pool of cohesin complexes containing AtRAD21.1 (red rings) in the cell, hence contributing to promote and enhance sister chromatid cohesion. (C) The DNA dsb damage induced increase of AtRAD21.3 transcript content (that occurs after that of AtRAD21.1), is also expected to contribute to increase the pool cohesin complexes containing AtRAD21.3 (green rings). These cohesin complexes (green circles) may reinforce sister chromatid cohesion, or they may replace (all or some of) the AtRAD21.1 cohesin complexes (red rings) that generated the de novo cohesion. It has been proposed that the increased cohesion facilitates DNA dsb repair by promoting physical proximity between the chromatid with a DNA dsb (orange) and its intact sister chromatid (black). Green and red rings: cohesin complexes tethering the two sister chromatids (black and orange). Yellow lines: the site of the DNA dsb. Flash (yellow): the DNA dsb inducing agent.

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