Fig. 4
Phylogenetic trees of folate-metabolism related proteins which all plant homologs are grouped into one class. The phylogenetic trees of folate-metabolism related proteins from maize, sorghum, millet, rice, Arabidopsis, human, rat, mouse, yeast, and E. coli constructed by MEGA version 5 using neighbour-joining algorithms. All plant homologs are grouped into one class. a, GDCT; b, GDCP; c, SHMT1; d, 10-FDF; e, FTHS; f, GTPCHI; g, DHFR; h, MS; i, FPGS; j, MTHFR. The accession numbers used in this figure are: GCST SORBI (Swiss-Prot: C5YG66), GCST SETIT (K3Y7N9), GCST ORYSJ (Q01KC0), GCST ARATH (O65396), GCST ECOLI (P27248), GCST YEAST (P48015), GCST HUMAN (P48728), GCST MOUSE (Q8CFA2); GCSP SORBI (C5YS41), GCSP SETIT (K3XDV1), GCSP1 ORYSJ (Q6RS61), GCSP2 ORYSJ (Q6V9T1), GCSP1 ARATH (Q94B78), GCSP2 ARATH (O80988), GCSP ECOLI (P33195), GCSP YEAST (P49095), GCSP HUMAN (P23378), GCSP MOUSE (Q91W43); SHMT1 SETIT (K4A8N1), SHMT1 ORYSJ (Q10D68), SHMT1 ARATH (Q9SZJ5), GLYA ECOLI (P0A825), GLYM YEAST (P37292), SHMT1 HUMAN (P34896), SHMT1 RAT (Q6TXG7), SHMT1 MOUSE (P50431); PURU SORBI (C5WMW1), PURU-1 SETIT (K4ACX9), PURU-2 SETIT (K3Z0D3), PURU ORYSJ (Q10T42), PURU1 ARATH (Q93YQ3), PURU2 ARATH (F4JP46), PURU ECOLI (P37051); FTHS SORBI (C5X255), FTHS SETIT (K3ZR21), FTHS ORYSJ (Q0J1E1), FTHS ARATH (Q9SPK5), CITC YEAST (P07245), C1TM YEAST (P09440), C1TC HUMAN (P11586), C1TC RAT (P27653), C1TC MOUSE (Q922D8); GCH1 SETIT (K3Z5X1), GCH1 ARATH (Q9SFV7), GCH1 ECOLI (P0A6T5), GCH1 YEAST (P51601), GCH1 HUMAN (P30793), GCH1 RAT (P22288), GCH1 MOUSE (Q05915); DRTS SORBI (C5Y2E9), DRTS-1 SETIT (K3ZI20), DRTS-2 SETIT (K3ZSB7), DRTS-1 ORYSJ (Q2R481), DRTS-2 ORYSJ (Q2QRX6), DRTS-1 ARATH (Q05762), DRTS-2 ARATH (Q05763), DRTS-3 ARATH (Q9SIK4); MS2 SORBI (Q8W0Q7), MS1 SETIT (K3Z414), MS2 SETIT (K4A622), METE1 ORYSJ (Q2QLY5), METE2 ORYSJ (Q2QLY4), MS1 ARATH (O50008), MS2 ARATH (Q9SRV5), MS3 ARATH (Q0WNZ5), METH ECOLI (P13009), METE YEAST (P05694), METH HUMAN (Q99707), METH RAT (Q9Z2Q4), METH MOUSE (A6H5Y3); FPGS-1 SORBI (C5WWE5), FPGS-2 SORBI (C5WMM8), FPGS-1 SETIT (K4A7H2), FPGS-2 SEITI (K4A839), FPGS-1 ORYSJ (Q337F3), FPGS-2 ORYSJ (Q10SU1), FPGS-3 ORYSJ (B9G6I2), FPGS1 ARATH (F4K2A1), FPGS2 ARATH (F4J2K2), FPGS3 ARATH (Q8W035), FOLC ECOLI (P08192), FOLE YEAST (Q08645), FOLC YEAST (P36001), FOLC HUMAN (Q05932), FOLC-2 HUMAN (Q5JU23), FOLC RAT (M0R401), FOLC MOUSE (P48760); MTHR SORBI (C5WVY7), MTHR SETIT (K4AMY6), MTHR ORYSJ (Q75HE6), MTHR1 ARATH (Q9SE60), MTHR2 ARATH (O80585), METF ECOLI (P0AEZ1), MTHR1 YEAST (P46151), MTHR2 YEAST (P53128), MTHR HUMAN (P42898), MTHR RAT (D4A7E8), MTHR MOUSE (Q9WU20); SHMT1 SORBI (phytozome: Sb01g008690.1), GCH1 SORBI (Sb06g031800.1), GCH1 ORYSJ (LOC_Os04g56710.1), and MS1 SORBI (Sb08g022210.1)