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Fig. 5 | BMC Plant Biology

Fig. 5

From: Tracing the biosynthetic origin of limonoids and their functional groups through stable isotope labeling and inhibition in neem tree (Azadirachta indica) cell suspension

Fig. 5

Tracing the flow of 13C from glucose through MVA and MEP pathway for the biosynthesis of isoprene unit. The black dot representsthe 13C carbon derived from 1-13C label /1,6 -13C of D-glucose and the blue one from 2-13C label of D-glucose. Mevinolin and fosmidomycin are the inhibitors for HMGR and DXR, respectively. AACT, acetoacetyl-CoA thiolase; HMGS, 3-hydroxy-3 methyl glutaryl coenzyme A synthase; HMGR, 3-hydroxy-3-methyl glutaryl coenzyme A reductase; MK, mevalonate kinase; PMK, 5-phosphomevalonate kinase; DPMDC, diphosphomevalonate decarboxylase; IPPI, isopentenyl diphosphate isomerase; DXS,1-deoxy-D-xylulose-5-phosphate synthase; DXR, 1-deoxy-D-xylulose-5-phosphate reductoisomerase; MCT, 2-C-methyl-D-erythritol-4 phosphate cytidyltransferase; CMK, 4-(Cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase; MDS, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; HDS, 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; HDR, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

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BMC Plant Biology

ISSN: 1471-2229

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