Metabolite name | Relative concentration | Fold changes Log2(LN/CK) | |||||
---|---|---|---|---|---|---|---|
C | W | ||||||
CK | LN | CK | LN | C | W | ||
Aliphatic amino acid | Asparagine | 0.51 ± 0.06 | 0.06 ± 0.02 | 0.06 ± 0.01 | 0.22 ± 0.05 | −3.20** | 1.95* |
Aspartic acid | 1.53 ± 0.33 | 0.79 ± 0.24 | 0.07 ± 0.04 | 0.33 ± 0.09 | −0.95 | 2.28* | |
Threonine | 1.43 ± 0.03 | 1.24 ± 0.15 | 0.02 ± 0.00 | 0.03 ± 0.01 | −0.20 | 0.97* | |
Cycloleucine | 0.85 ± 0.06 | 1.31 ± 0.55 | 30.89 ± 5.31 | 44.38 ± 8.78 | 0.63 | 0.52 | |
Isoleucine | 5.58 ± 0.20 | 2.58 ± 0.19 | 0.38 ± 0.01 | 1.33 ± 0.25 | −1.11 | 1.79** | |
L − proline | 2.46 ± 1.02 | 5.06 ± 0.68 | 0.11 ± 0.01 | 0.81 ± 0.18 | 1.04 | 2.85** | |
L − homoserine | 0.29 ± 0.05 | 0.33 ± 0.02 | 1.04 ± 0.21 | 2.42 ± 0.26 | 0.19 | 1.22** | |
Valine | 5.63 ± 0.87 | 4.42 ± 0.09 | 37.13 ± 3.86 | 47.46 ± 5.60 | −0.35* | 0.35 | |
Alanine | 2.46 ± 0.32 | 1.61 ± 0.52 | 0.09 ± 0.01 | 0.26 ± 0.03 | −0.61 | 1.57** | |
Glycine | 3.51 ± 0.54 | 2.62 ± 0.46 | 1.07 ± 0.15 | 1.27 ± 0.30 | −0.42* | 0.25 | |
Serine | 8.50 ± 0.84 | 12.51 ± 2.47 | 0.01 ± 0.00 | 0.06 ± 0.01 | 0.56 | 2.32* | |
Sarcosine | 1.59 ± 0.17 | 2.07 ± 0.23 | 0.81 ± 0.15 | 2.97 ± 0.63 | 0.38 | 1.88* | |
Aromatic amino acid | Phenylalanine | 0.71 ± 0.21 | 0.49 ± 0.04 | 0.08 ± 0.03 | 0.17 ± 0.02 | −0.53 | 1.01* |
Non − protein nitrogen | Galactosamine | 0.08 ± 0.01 | 0.10 ± 0.00 | 9.79 ± 4.25 | 17.95 ± 3.79 | 0.26 | 0.87 |
GABA | 8.34 ± 0.78 | 6.38 ± 1.42 | 0.10 ± 0.02 | 0.19 ± 0.02 | −0.39 | 0.92* | |
Maleimide | 0.93 ± 0.08 | 0.77 ± 0.18 | 0.23 ± 0.01 | 0.31 ± 1.10 | −0.27 | 0.43* | |
Mannosamine | 0.83 ± 0.09 | 1.06 ± 0.08 | 3.67 ± 0.66 | 10.39 ± 0.63 | 0.36 | 1.50** | |
Ethanolamine | 19.62 ± 0.57 | 20.71 ± 4.45 | 30.85 ± 6.18 | 61.33 ± 6.31 | 0.08 | 0.99* | |
Sugars and polyols | Glycerol | 14.12 ± 0.18 | 11.49 ± 0.27 | 0.10 ± 0.01 | 0.20 ± 0.00 | −0.30 | 0.95** |
Monopalmitin | 0.04 ± 0.01 | 0.16 ± 0.05 | 25.16 ± 8.47 | 106.06 ± 10.98 | 1.83 | 2.08 | |
Myo − inositol | 19.77 ± 0.48 | 28.56 ± 1.03 | 0.60 ± 0.07 | 1.48 ± 0.41 | 0.53** | 1.31** | |
Palatinitol | 0.04 ± 0.00 | 0.06 ± 0.00 | 0.29 ± 0.06 | 0.52 ± 0.11 | 0.78** | 0.85 | |
Arabitol | 1.46 ± 0.14 | 1.57 ± 0.06 | 0.12 ± 0.01 | 0.57 ± 0.10 | 0.10 | 2.23** | |
Threitol | 0.84 ± 0.23 | 1.25 ± 0.14 | 0.17 ± 0.01 | 0.37 ± 0.06 | 0.57 | 1.15* | |
Erythritol | 0.08 ± 0.02 | 0.20 ± 0.03 | 1.23 ± 0.25 | 4.26 ± 0.15 | 1.24** | 1.79* | |
Sucrose | 36.97 ± 1.51 | 29.08 ± 1.92 | 30.81 ± 9.34 | 2.64 ± 0.02 | −0.35** | −3.54* | |
Maltose | 3.03 ± 0.42 | 2.37 ± 0.32 | 0.12 ± 0.01 | 0.22 ± 0.05 | −0.36 | 0.91 | |
Melezitose | 0.24 ± 0.11 | 0.23 ± 0.02 | 0.004 ± 0.00 | 0.03 ± 0.00 | −0.11 | 2.77** | |
L − threose | 0.12 ± 0.03 | 0.12 ± 0.01 | 4.15 ± 0.23 | 4.96 ± 0.75 | −0.04 | 0.26 | |
Fucose | 0.17 ± 0.06 | 0.10 ± 0.00 | 0.08 ± 0.00 | 0.12 ± 0.01 | −0.81 | 0.68** | |
Xylose | 0.22 ± 0.03 | 0.37 ± 0.03 | 6.36 ± 0.17 | 10.71 ± 2.81 | 0.75* | 0.75 | |
Galactose | 0.87 ± 0.20 | 1.70 ± 0.15 | 0.05 ± 0.01 | 0.08 ± 0.01 | 0.96* | 0.53 | |
Fructose-6 − biphosphate | 0.06 ± 0.01 | 0.22 ± 0.04 | 0.06 ± 0.00 | 0.15 ± 0.01 | 1.83** | 1.25** | |
Glucose−6 − phosphate | 0.03 ± 0.00 | 0.14 ± 0.04 | 0.95 ± 0.15 | 1.55 ± 0.22 | 2.49* | 0.70 | |
Organic acid | Lactic acid | 2.17 ± 0.21 | 4.79 ± 0.91 | 0.69 ± 0.09 | 0.93 ± 0.17 | 1.15* | 0.44 |
Galactonic acid | 0.63 ± 0.08 | 2.08 ± 0.25 | 1.05 ± 0.35 | 1.42 ± 0.14 | 1.72** | 0.44 | |
Glyceric acid | 8.33 ± 0.94 | 8.12 ± 2.57 | 9.87 ± 0.91 | 15.71 ± 2.56 | −0.04 | 0.67* | |
Pyruvic acid | 7.98 ± 0.17 | 2.84 ± 0.71 | 0.34 ± 0.08 | 0.85 ± 0.11 | −1.49** | 1.31* | |
Fumaric acid | 44.89 ± 4.92 | 7.64 ± 1.23 | 0.06 ± 0.02 | 0.07 ± 0.01 | −2.55** | 0.11 | |
Malic acid | 0.16 ± 0.01 | 0.11 ± 0.01 | 3.39 ± 0.57 | 5.29 ± 1.30 | −0.50* | 0.64 | |
Citramalic acid | 0.35 ± 0.06 | 0.23 ± 0.02 | 0.16 ± 0.00 | 0.26 ± 0.04 | −0.62 | 0.71* | |
Succinic acid | 7.73 ± 0.72 | 7.15 ± 1.28 | 6.33 ± 1.30 | 10.06 ± 0.74 | −0.11 | 0.67* | |
Ketoisocaproic acid | 0.02 ± 0.00 | 0.03 ± 0.00 | 11.15 ± 0.46 | 22.50 ± 0.38 | 0.55** | 1.01** | |
2 − Deoxytetronic acid | 18.32 ± 3.67 | 30.44 ± 2.30 | 3.47 ± 0.61 | 9.71 ± 1.54 | 0.73 | 1.49 | |
Oxalic acid | 0.19 ± 0.03 | 0.24 ± 0.04 | 0.12 ± 0.01 | 0.26 ± 0.04 | 0.71 | 2.26* | |
Propionic acid | 0.14 ± 0.03 | 0.17 ± 0.01 | 0.83 ± 0.20 | 3.03 ± 0.34 | 0.34 | 1.13** | |
Maleic acid | 14.74 ± 1.66 | 7.75 ± 1.14 | 1.73 ± 0.20 | 9.20 ± 3.54 | 0.28* | 1.86 | |
Gluconic acid | 0.11 ± 0.01 | 0.12 ± 0.02 | 0.10 ± 1.03 | 0.34 ± 0.09 | −1.10 | 0.58* | |
Glucoheptonic acid | 1.98 ± 0.13 | 2.64 ± 0.20 | 1.71 ± 0.49 | 3.57 ± 0.71 | −0.93 | 2.41 | |
Fatty acids | Butyrate | 0.31 ± 0.01 | 0.15 ± 0.07 | 25.66 ± 1.03 | 38.35 ± 2.81 | 0.13 | 1.83* |
Isobutyric acid | 0.26 ± 0.05 | 0.43 ± 0.04 | 2.53 ± 0.38 | 12.14 ± 3.61 | 0.41 | 1.06 | |
Stearic acid | 0.16 ± 0.01 | 0.42 ± 0.07 | 1.92 ± 0.10 | 3.50 ± 0.53 | 1.43* | 0.87* | |
Linoleic acid | 0.01 ± 0.00 | 0.02 ± 0.00 | 8.30 ± 2.49 | 22.03 ± 0.87 | 0.83* | 1.41** | |
Linolenic acid | 0.34 ± 0.03 | 1.14 ± 0.16 | 3.19 ± 0.40 | 2.49 ± 0.33 | 1.75** | −0.36 | |
Palmitic acid | 0.55 ± 0.04 | 1.64 ± 0.22 | 0.27 ± 0.02 | 0.82 ± 0.26 | 1.56** | 1.59 | |
Butyric acid | 0.31 ± 0.22 | 0.14 ± 0.01 | 0.95 ± 0.10 | 0.67 ± 0.04 | −1.09 | −0.52* | |
Phenylpropanoids | Neohesperidin | 0.81 ± 0.11 | 2.14 ± 0.45 | 0.17 ± 0.03 | 1.27 ± 0.24 | 1.40* | 2.90** |
Salicylic acid | 1.23 ± 0.00 | 1.60 ± 0.17 | 2.28 ± 0.24 | 7.70 ± 1.42 | 0.38 | 1.76** | |
Trans − cinnamate | 0.36 ± 0.03 | 1.08 ± 0.20 | 1.43 ± 0.11 | 4.59 ± 0.74 | 1.59* | 1.68** | |
Naringin | 0.01 ± 0.00 | 0.06 ± 0.02 | 0.78 ± 0.24 | 1.81 ± 0.59 | 3.04* | 1.21 | |
Ferulic acid | 0.81 ± 0.08 | 1.16 ± 0.05 | 0.47 ± 0.04 | 0.31 ± 0.03 | 0.52* | −0.61** | |
Caffeic acid | 0.01 ± 0.00 | 0.02 ± 0.00 | 6.48 ± 0.68 | 5.12 ± 0.54 | 1.16 | −0.34 | |
Prunin | 0.29 ± 0.02 | 0.19 ± 0.07 | 2.41 ± 0.51 | 5.61 ± 0.19 | −0.61* | 1.22* |