Table 1 Proteins engaged in m6A metabolism in plants
From: In search of the mRNA modification landscape in plants
Abbreviation | Full name | Plant Species | Functions | Cellular localization | Phenotype of the mutant with decrease expression |
|---|---|---|---|---|---|
MTA | mRNA adenosine methylase | Arabidopsis (Arabidopsis thaliana) | form m6A methylation complex | nucleus | • mta, mtb, fip37 and vir are embryo-lethal • mature mta, mtb, fip37 and vir plants show alerted vascular development, gravitropic response, roots growth and flowering timing • mta mutants are characterized by small, bushy rosettes and alerted flower and trichome architecture • hakai-1 and hakai-2 mutants resembled wild type plants [23,24,25,26,27], |
MTB | |||||
FIP37 | FKB12 Interacting Protein 37 kD | ||||
VIR | VIRILIZER | ||||
HAKAI | |||||
ECT1–13 | FKB12 Interacting Protein 37 kD | Arabidopsis (Arabidopsis thaliana) | confirmed or putative m6A binding proteins engaged in downstream responses including regulation of mRNA lifetime | Various YTH-domain proteins were detected in cytoplasm and nucleus or ubiquitously in cells, depending on the plant species and specific protein | • ect2 mutant showed increased trichome branching • double ect2/ect3 mutants show increased trichome branching and delayed leave formation accompanied by changes in leaves shape [28,29,30,31,32,33,34] |
MhYTP1–15 | YTH-domain protein | Chinese crab apple (Malus hupehensis) | |||
OsYTH1–12 | YTH-domain protein | Rice (Oryza sativa) | |||
CsYTH1–5 | YTH-domain protein | Cucumber (Cucumis sativus) | |||
ALKB10B | Alpha-ketoglutarate-dependent dioxygenase 10B | Arabidopsis (Arabidopsis thaliana) | mediates m6A demethylation | not examined | • hampered growth and delayed flowering [21] |