|
T0
|
T1
|
T8
|
---|
Amino acids
| | | |
Alanine
|
1.00 ± 0.04
|
1.22 ± 0.06*
|
1.48 ± 0.12*
|
Alanine
|
1.00 ± 0.05
|
0.73 ± 0.03*
|
1.92 ± 0.14*
|
Asparagine
|
1.00 ± 0.13
|
0.61 ± 0.07*
|
0.51 ± 0.05*
|
Aspartic acid
|
1.00 ± 0.05
|
0.74 ± 0.07*
|
1.07 ± 0.14
|
Butyric acid, 4-amino
|
1.00 ± 0.06
|
0.62 ± 0.10*
|
0.59 ± 0.09*
|
Cysteine
|
1.00 ± 0.16
|
0.83 ± 0.10
|
0.94 ± 0.11
|
Glutamic acid
|
1.00 ± 0.05
|
0.94 ± 0.05
|
0.67 ± 0.06*
|
Glutamine
|
1.00 ± 0.07
|
0.66 ± 0.06*
|
0.76 ± 0.10
|
Isoleucine
|
1.00 ± 0.04
|
1.31 ± 0.08*
|
1.73 ± 0.13*
|
Lysine
|
1.00 ± 0.05
|
0.71 ± 0.05*
|
0.89 ± 0.08
|
Methionine
|
1.00 ± 0.05
|
2.29 ± 0.14*
|
2.30 ± 0.18*
|
Phenylalanine
|
1.00 ± 0.08
|
1.67 ± 0.05*
|
1.24 ± 0.07
|
Proline
|
1.00 ± 0.05
|
2.01 ± 0.09*
|
1.53 ± 0.12*
|
Pyroglutamic acid
|
1.00 ± 0.03
|
0.71 ± 0.04*
|
0.63 ± 0.07*
|
Serine
|
1.00 ± 0.05
|
4.23 ± 0.21*
|
7.17 ± 0.47*
|
Threonine
|
1.00 ± 0.03
|
1.71 ± 0.09*
|
2.69 ± 0.15*
|
Valine
|
1.00 ± 0.07
|
1.03 ± 0.04
|
1.36 ± 0.08*
|
Organic acids
| | | |
Benzoic acid
|
1.00 ± 0.04
|
1.13 ± 0.08
|
1.08 ± 0.05
|
Citric acid
|
1.00 ± 0.29
|
1.30 ± 0.59
|
0.95 ± 0.35
|
Dehydroascorbic acid
|
1.00 ± 0.09
|
1.43 ± 0.41
|
1.46 ± 0.34
|
Fumaric acid
|
1.00 ± 0.05
|
1.56 ± 0.23
|
3.13 ± 0.27*
|
Galactonic acid
|
1.00 ± 0.05
|
0.85 ± 0.04
|
0.99 ± 0.08
|
Glyceric acid
|
1.00 ± 0.05
|
2.11 ± 0.17*
|
4.99 ± 0.36*
|
Lactic acid
|
1.00 ± 0.12
|
0.94 ± 0.09
|
1.01 ± 0.17
|
Malic acid
|
1.00 ± 0.05
|
1.08 ± 0.20
|
2.02 ± 0.22*
|
Nicotinic acid
|
1.00 ± 0.06
|
1.00 ± 0.05
|
0.93 ± 0.05
|
Phosphoric acid
|
1.00 ± 0.26
|
0.98 ± 0.30
|
0.96 ± 0.30
|
Succinic acid
|
1.00 ± 0.03
|
0.84 ± 0.08
|
0.53 ± 0.05*
|
Sugars
| | | |
Lyxose
|
1.00 ± 0.06
|
1.13 ± 0.02
|
1.32 ± 0.05*
|
Fructose
|
1.00 ± 0.02
|
2.59 ± 0.14*
|
0.81 ± 0.04*
|
Fucose
|
1.00 ± 0.05
|
1.00 ± 0.04
|
0.93 ± 0.04
|
Glucose
|
1.00 ± 0.08
|
1.28 ± 0.06*
|
0.61 ± 0.04*
|
Glucose, 1,6-anhydro
|
1.00 ± 0.08
|
1.63 ± 0.08*
|
1.67 ± 0.12*
|
Inositol
|
1.00 ± 0.04
|
0.87 ± 0.04
|
0.73 ± 0.04*
|
Sorbitol
|
1.00 ± 0.05
|
0.91 ± 0.05
|
1.09 ± 0.09
|
Sucrose
|
1.00 ± 0.05
|
1.51 ± 0.14*
|
1.27 ± 0.17
|
Others
| | | |
Mannopyranoside, 1-O-methyl-
|
1.00 ± 0.07
|
1.09 ± 0.03
|
0.94 ± 0.07
|
Ornithine
|
1.00 ± 0.10
|
1.84 ± 0.09*
|
1.30 ± 0.15
|
Putrescine
|
1.00 ± 0.09
|
1.12 ± 0.07
|
1.57 ± 0.08*
|
Spermidine
|
1.00 ± 0.16
|
2.47 ± 0.18*
|
4.11 ± 0.45*
|
Threitol
|
1.00 ± 0.05
|
0.78 ± 0.05*
|
0.78 ± 0.05
|
- Data are normalized to the mean response calculated for the time point (T0) of each measured batch. Values are presented as the mean ± SE of 6 biological determinations. Asterisks at T1 and T8 indicate values significantly different from T0, as calculated by t test (increase and decrease) with p-value < 0.01