Fig. 9

Interactions of the SeMTC enzymes and ligands. The left panel is the overall view, and the right panel is the focused view. The SeMTC enzymes are shown on the surface, the amino acid residues at the binding site are gray-blue, and the ligands are heavily yellow. The gray dotted line represents hydrophobic interactions, the solid blue line represents the hydrogen bond, the dashed yellow line represents the salt bridge, and the red dashed line represents a π-cation interaction. ChMAT4: Interactions of the binary ChMAT-ATP complex with SeMet. ChCOMT9-1: Interactions of the binary ChCOMT with SeAM. ChSAHH1-2: Interactions of the binary ChSAHH with SeAH. ChMTR3-2: Interactions of the binary ChMTR-5-methyltetrahydrofolate complex with SeHcys. CS: putative binding mode of SeMTC enzymes and ligands to model the protein structure at the catalytic site. MBS: SeMTC enzymes and ligands are in a putative binding mode that mimics the protein structure at the site of minimum binding energy, the site of maximum affinity binding